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Clinical trials that are designed to help inform practice in the real world are known as pragmatic trials. They are typically described as a focus on the practical aspects of study design, including the recruitment process and consent, adhering and the use of standard equipment.

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Another example of a practical trial is the Home Blood Pressure Management (HBPM) study, which utilized different investigators and participants from different geographical regions. This type of heterogeneity is required for pragmatic trials to be valid and reduces bias in the results. A high degree of heterogeneity, however can result in problems with the trial design.

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Pragmatic Play has earned a name for itself by providing high-quality games and a superior user experience. Its software is designed to work with mobile devices and supports different languages. Despite its relative youth it has already established itself as a leading gaming platform for casinos. The most recent releases include Wolves, a 5-reel video slot with a healthy RTP and impressive graphics. Other notable games include Wolf Gold and Chilli Heat.

The purpose of pragmatic trials is to mimic real-life scenarios and gain maximum credibility externally. They are typically requested by practitioners and policymakers to inform their decisions. They are also a good way to identify the causality between an intervention and its results. They should not, however, be used to replace explanation studies.

The idea of pragmatism is controversial, and there are questions regarding whether pragmatic trials could replace tests for explanations or if they should serve as an addition to them. Schwartz and Lellouch1 proposed a distinction between explanatory studies, which support the validity of a physiological or clinical hypothesis, as well as pragmatic trials, that inform the practice and policy decision-making. They also suggested a framework known as PRECIS for pragmatic trials.2 This tool attempted to define the elements of a pragmatic research study, including recruitment, design, delivery of the intervention and follow-up.

There is a growing trend in the number of pragmatic trials that are published. A recent Medline search using the keywords pragmatic and naturalistic, restricted to randomized controlled trials (RCTs) resulted in 34 articles, shown in red in Figure 2. This indicates that the health sciences community is becoming more aware of the importance of pragmatic thinking. However, it is important to keep in mind that the majority of these trials were conducted in primary care settings.