18.2 Main Histocompatibility Complexes And Antigen-Presenting Cells - …
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Macrophages and dendritic cells use similar mechanisms for processing and presentation of antigens and their epitopes in affiliation with MHC II; B cells use somewhat totally different mechanisms that will be described additional in B Lymphocytes and Humoral Immunity. For now, we will deal with the steps of the method as they pertain to dendritic cells. After a dendritic cell acknowledges and attaches to a pathogen cell, the pathogen is internalized by phagocytosis and is initially contained within a phagosome. Lysosomes containing antimicrobial enzymes and chemicals fuse with the phagosome to create a phagolysosome, where degradation of the pathogen for antigen processing begins. APCs do not current all doable epitopes to T cells; solely a choice of probably the most antigenic or immunodominant epitopes are presented.
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