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The BIOFIRE System and Your Immune System

The BIOFIRE System offers syndromic testing for infectious illnesses, allowing healthcare professionals to choose the appropriate test the first time. Patients benefit from quicker diagnosis and more targeted treatment. Clinicians benefit from a better stewardship of antibiotics. Labs save money and gain efficiency.

The BioFire FilmArray Pneumonia plus panel (PN panel) tests native sputum, endotracheal aspirate, and bronchoalveolar lavage specimens (including mini-BAL) for 33 clinically relevant pathogens and antimicrobial resistance genes. The panel provides semiquantitative results in about an hour.

Respiratory

The burning of biomass (wood plants, trees and other organic materials) produces gaseous pollutants as well as fine particles of matter that negatively impact the respiratory system. Climate change can make it more difficult to reverse the negative effects of forest fires to human health.

In the United States, wildfire smoke has been associated with hospitalizations for respiratory diseases like asthma, COPD and lung cancer. Additionally, this kind of air pollution can be a risk factor for cardiovascular disease and a significant contributing factor to the burden of disease for the most vulnerable population which includes those who are of lower socioeconomic status (SES).

The wildfires have caused unhealthy levels of air pollution in many communities during the COVID-19 epidemic. However the response of public health officials to this environmental issue has been sporadic and mostly focused on communication about the management of symptoms. This knowledge gap is alarming given the evidence that smoking and other sources of poor quality air can lead to health problems.

Researchers are now evaluating how to best protect the public's health during future events of this kind. NIH invests in research on this critical public health issue through the BLUE CORAL and FIRE CORAL studies.

For the first time an prospective cohort study will assess long-term outcomes from exposure to smoke from wildfires as well as other sources. FIRE CORAL recruits adult participants who are hospitalized for COVID-19 index episodes and speak English or Spanish however, they are not pregnant. The protocol for FIRE CORAL includes a set of tests conducted in-person, objectively measuring pulmonary function testing and ethanol fireplace insert fuel fireplace; http://seoulsamsung.kr, lung imaging and functional assessment.

Smoke and other particles can cause or worsen respiratory conditions such as emphysema, COPD, and pneumonia. Smoke exposure can have adverse effects on health. To lessen or stop these effects, you should avoid outdoor activities and use the EPA "N95" mask. The mask is designed to trap small particles.

Smoking cigarettes can cause irritation of the throat and eyes and can cause the nose to run. To help reduce symptoms, drink plenty of water, and take medications that reduce inflammation, such as corticosteroids.

Bloodstream

The bloodstream is the first line of defense against germs that invade your system. Dendritic cells, which are special cells, act as a call center your bio-ethanol fire department. They are able to collect antigens from germs and release proteins that signal other white cells to fight off them. The total white blood cells, differentials and band cells grew after firefighters' firefighting activities as compared to levels following intense exercise without firefighting.

Skin

Dermatologists were concerned that the smoke and ash that resulted from the California wildfires could have negative effects on the skin of those who were exposed to them. Maria Wei, a graduate student at the University of California, Irvine is researching how extreme fire pollution affects skin. Her research was published on April 22, 2012 in Scientific Reports.

The study of Wei shows that the temperature of the skin changes dependent on the amount of time the body has been exposed. It takes upwards of two hours for the skin to reach its flash point, the place where it begins to burn and then turns into a ashy. It is important to avoid staying near a fire pit or campfire, and you should always wear protective clothing when going outside during a hot or humid day.

Forest fires will continue to happen, despite the precautions taken to prevent wildfire pollution. Wei is predicting that the number of people suffering the effects of wildfires will rise as climate change causes more and more forests to be burned. This means that more people will need to wear long sleeves and hats and thick moisturizers.

Wildfire air pollution can also increase the severity of atopic skin dermatitis which is a condition that causes itchy skin for many people. She says that the particles in smoke can clog pores which can cause skin irritation.

Atopic dermatitis can also make people more sensitive to UV light. This can be made worse by smoke from wildfires. This can cause people to be more likely to seek out tanning salons, and could cause the skin to get darker with less protection than they should.

A treatment with ice and fire can help reduce atopic skin symptoms of dermatitis, but it is not advised for anyone who has an open wound or rash. This treatment is not recommended for those with active acne, or if you're pregnant or nursing. The IS Clinical indoor bio ethanol fire & Ice Facial at Novuskin, Las Vegas' premiere membership MedSpa, is an intensive result-driven facial that bridges the gap between a mild facial and a peel without needing any downtime. It's designed to smooth the skin, improve rosacea symptoms, traditional Bioethanol Fireplace decrease the appearance of acne scars, reduce wrinkles, and promote cellular renewal. This is a great treatment to provide your skin with a radiant glow.

Infections

The human body is a multi-faceted network of organs and tissues that work to guard us against infections. Infections are caused by microscopic microorganisms like parasites, viruses, bacteria and fungi that infect healthy cells and cause them to replicate out of control. When this happens, your immune system may respond with symptoms of illness. These symptoms can include anything from a swollen or achy nose to a stomach upset and can include a fever that is high, swollen glands, and an skin rash. Your symptoms can be affected by the nature of the infection, its location, and even your temperature.

Infections can spread in different ways, but they are most often spread through airborne droplets that remain after coughing or sniffling. This is how bacterial infections such as tuberculosis, strep and meningococcal illness and viral infections like the common cold and influenza spread. Certain bacterial infections, such as skin infections or sexually transmitted diseases (STIs) such as gonorrhea or chlamydia are spread through direct contact with affected mucous or tissue surfaces, or indirectly through surfaces that are contaminated. Some bacterial diseases are transmitted by bugs such as mosquitoes, ticks or fleas, and are spread by bites from these bugs you.

Viruses and some parasites are small enough to enter your bloodstream and infect your cells, which can lead to serious diseases such as the common cold and AIDS. Fungi can cause skin problems like athlete's feet and ringworm, while others infect the respiratory system and the nervous system.

The BioFire Panel employs our revolutionary FilmArray technology to analyze the bronchoalveolar and sputum samples to determine a comprehensive list of pathogens that are involved in upper respiratory infection. The kit includes an reagent pouch that houses all the necessary chemistry to perform reverse transcription PCR, multiplex nested testing and detection using a single machine. This is a simple solution that assists clinicians identify and treat patients with a variety respiratory symptoms. This test has received an Emergency Use Authorization and is available through bioMerieux's CLIA moderate and high-complexity labs.