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Pragmatic trials are those that are designed to provide information for the practice of clinical trials in real life. They are often focused on the practical aspects of the research design, like the recruitment process and consent in adherence, as well as the use of commonly available equipment.

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While Pragmatic Play is known for its slot machines, it also offers table games like Bitcoin baccarat and Roulette. They have over dozen licensed games, and their software is renowned for its reliability and security. Their products are available across multiple languages and include several betting options, including live dealer tables.

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Pragmatic is a software company, offers a variety of casino games on online gambling platforms. Its iGaming software is used by top operators and land based casinos. The company offers front-end site design tools, analysis and promotions, marketing security payment systems, customer service and bug reporting. The company also offers a safe environment with high-quality graphics, gaming and security.

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Another example of a pragmatic trial is the Home Blood Pressure Management (HBPM) study, which used different investigators and had participants from various geographical areas. This type of heterogeneity which is essential for pragmatic trials to be reliable and lessen the chance of bias is also essential. However, too much heterogeneity could cause issues with the design of the trial.

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In addition to their mobile-friendly slots, Pragmatic Play also offers tables games and live dealer casinos. The company is licensed and is regulated by various regulatory bodies, including the Malta Gaming Authority and UK Gambling Commission. The games are supported by top-of-the-line encryption technology, and the company's security team is on hand to help players resolve any issues they might have.

Pragmatic Play's slot games are popular with newbies as well as experienced players. They feature modern designs and traditional themes. They have a variety of paylines and bonus rounds and a majority of them have progressive jackpots. They are also not very volatile and you can expect to have a long-lasting gaming session with them.

Pragmatic Play offers a large selection of games that you can play at no cost before deciding whether to pay for them. These games are free and can be played on any device including laptops, desktops and even smartphones. You can play them wherever that you connect to the internet. They are simple to navigate. Some Pragmatic Play sites even allow players to test their luck on the go with an exercise mode. This will allow you to familiarize yourself with game rules and features before playing with real money.

Legality

Pragmatic Play has earned a reputation for providing top-quality games and an outstanding user experience. Its software is designed to work with mobile devices and is compatible with multiple languages. It has earned itself the status of one of the top casino gaming platforms despite its relatively young age. The latest releases include Wolves, a 5-reel video slot with a healthful RTP and stunning graphics. Other notable games include Wolf Gold and Chilli Heat.

Pragmatic trials aim to mimic real-world situations and have the highest external validity. They are usually requested by practitioners and policy makers to inform their decision making. They can also be used to assess the causal relationship between an intervention with its outcomes. However, they should not be used as a substitute for explanatory trials.

The concept of pragmatism is controversial and there are doubts about whether pragmatic trials can be used to replace explanation tests or if they are a complement to them. Schwartz and Lellouch1 suggested a distinction between explanatory trials, which prove the validity of a clinical or physiological hypothesis, and pragmatic trials, which guide policy and practice decisions. They also proposed a framework called PRECIS for pragmatic trials.2 The tool was designed to define the characteristics of a pragmatic research study, including the recruitment, design, and delivery of the intervention and its follow-up.

The number of pragmatic trials is increasing. A recent Medline query that used the words pragmatic and naturalistic, which was restricted to randomised controlled trials (RCTs) returned 34 articles. These are highlighted in red on Figure 2. This is an indication that the health science community is becoming increasingly sensitized to the issue of pragmatics. It is important to note that the majority of these studies were conducted in primary care settings.